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New England Journal of Medicine , 387 (3), 205216

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95% CI, 0.630.85), with no significant interaction by sex ( Regarding safety, women experienced a higher incidence of genital infections while on SGLT-2 inhibitors, likely due to anatomical predisposition, which may impact treatment adherence ( For GLP-1 receptor agonists, the REWIND trial demonstrated a reduction in cardiovascular events with dulaglutide, with a trend toward greater benefit in women, although statistical significance was not achieved (RR 0.85

Some users report continued improvement during the first 1 to 2 weeks of rest as tissue remodeling continues without new peptide input